Thermo Fisher Scientific K-Ras Polyclonal Antibody
KRAS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot과 IHC(Paraffin)에서 사용 가능. 인간, 생쥐, 랫트 반응성. 1 mg/mL 농도의 액상 제품으로 -20°C 보관. 세포 증식 및 종양 연구에 적합.
- 카탈로그번호
- PA5102380
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KRAS (Accession P01116), corresponding to amino acid residues T148–M189 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851787 |
Product Specific Information
Antibody detects endogenous levels of total KRAS.
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and contributes to oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in the KRAS gene can result in leukemia (acute myelogenous, juvenile myelomonocytic), Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-102380_K-Ras_P01116-1_Rabbit.svg / PA5-102380_K-Ras_P01116-1_Rabbit_PDP.jpeg)
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