Thermo Fisher Scientific ARA70 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 ARA70(NCOA4) 단백질을 인식합니다. IHC 및 IHC-P에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. TBS 버퍼(0.1% BSA, 0.09% sodium azide) 용액 형태로 제공되며, 4°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 500 and 550 of human 70 kDa AR-activator (nuclear receptor coactivator 4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- 권장 보관 수명: 수령일로부터 1년
- 100% 서열 동일성 기준으로 고릴라 및 침팬지에서도 반응할 것으로 예측됨
Target Information
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG, and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of a chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, with highest expression in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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