Thermo Fisher Scientific p400 Polyclonal Antibody
Human EP400 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 40% 글리세롤 저장 버퍼를 사용합니다. 연구용으로만 사용 가능하며, 장기 보관 시 -20°C를 권장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EP400. Recombinant protein control fragment (Product #RP-106212). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791094 |
Product Specific Information
Immunogen sequence:
GTIKTSVTGT SMPTGAVSGN VIVNTIAGVP AATFQSINKR LASPVAPGAL TTPGGSAPAQ VVHTQPPPRA VGSPATATPD LVSMATTQGV RAVTSVTASA VVTTNLTPVQ TPARSLVPQV SQAT
Target Information
Component of the NuA4 histone acetyltransferase complex involved in transcriptional activation of select genes, principally by acetylation of nucleosomal histones H4 and H2A. This modification may alter nucleosome–DNA interactions and promote interaction of modified histones with other proteins that positively regulate transcription.
EP400 may be required for activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities are partly contributed by RUVBL1 and RUVBL2 association with EP400. May regulate ZNF42 transcription activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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