Thermo Fisher Scientific Cdc37 Polyclonal Antibody
Human CDC37 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 40% glycerol을 포함한 액상 형태입니다. 세포주기 및 HSP90 관련 신호전달 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDC37. Recombinant protein control fragment (Product #RP-102063). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789287 |
Product Specific Information
Immunogen sequence:
DGFSKSMVNT KPEKTEEDSE EVREQKHKTF VEKYEKQIKH FGMLRRWDDS QKYLSDNVHL VCEETANYLV IWCIDLEVEE KCALMEQVAH QTIVMQFILE LAKSLKVDPR ACFRQFFTKI KTADRQYMEG FNDELEAFKE RV
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs).
Cdc37 is associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to interact with many of the same cellular targets as Cdc37.
Cdc37 (also known as p50) forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src.
Cdc37 functions as a molecular chaperone both independently and with HSP90 and is essential for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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