Thermo Fisher Scientific Phospho-ATF2 (Ser490, Ser498) Polyclonal Antibody
ATF2 단백질의 Ser490/Ser498 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, -20°C 보관.
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Thermo Fisher Scientific Phospho-ATF2 (Ser490, Ser498) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Ser490/498 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ATF-2 (also called CRE-BP1) is a transcription factor that binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. It interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation activate ATF-2 through phosphorylation of Thr69 and Thr71 by SAPK and p38 MAPK.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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