Thermo Fisher Scientific LETMD1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 LETMD1 단백질에 대한 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Affinity chromatography로 정제된 1 mg/mL 액상 시약으로, -20°C에서 보관. 종양생성과 p53 억제 관련 LETMD1 연구용.
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Thermo Fisher Scientific LETMD1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LETMD1 (Accession Q6P1Q0), corresponding to amino acid residues T19–G69 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853706 |
Product Specific Information
Antibody detects endogenous levels of total LETMD1.
Target Information
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360-amino-acid single-pass membrane protein expressed in kidney, liver, skeletal muscle, heart, and brain.
It may be involved in tumorigenesis and function as a negative regulator of the p53 tumor suppressor.
Overexpression of HCCR-1 can cause mitochondrial dysfunction, leading to resistance to apoptosis and tumor progression.
HCCR-1 is considered a candidate biomarker for breast cancer and is highly expressed in various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix.
Six isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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