Thermo Fisher Scientific TET2 Polyclonal Antibody
TET2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IP, ChIP 등 다양한 응용에 사용 가능. 인간 유래 시료에 적합하며, 고순도 액상 형태로 제공. DNA 탈메틸화 연구 및 TET2 기능 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| ChIP assay (ChIP) | 5 µg | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 429–637 of TET2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient |
| RRID | AB_2553157 |
Product Specific Information
- Recommended positive control: TET2-transfected 293T cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), playing a key role in active DNA demethylation.
TET2 prefers 5-hydroxymethylcytosine in CpG motifs and mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC).
This conversion process is likely the first step in cytosine demethylation.
Additionally, TET2 recruits O-GlcNAc transferase (OGT) to CpG-rich transcription start sites of active genes, promoting histone H2B GlcNAcylation by OGT.
Mutations in the TET2 gene are associated with Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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