Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), PE
CD42b (GPIb alpha) 단백질을 인식하는 PE 결합 마우스 단클론 항체로, 인간 혈소판 및 거핵세포 표지에 사용됩니다. Flow Cytometry에 적합하며, 565/576 nm에서 여기/방출 특성을 가집니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AK2 |
| Immunogen | Human platelets |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913036 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD42b (GPIb alpha), a 135–145 kDa membrane glycoprotein expressed on platelets and megakaryocytes.
CD42b and CD42c (GPIb beta) form a disulfide-linked heterodimer (CD42b/c; 160 kDa), which associates noncovalently with CD42a and CD42d.
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor.
It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF.
CD42b, together with GPIb beta, GPIX, and GPV, forms the GPIb-IX-V receptor complex, critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.
CD42b binds to:
- von Willebrand factor (VWF)
- Thrombin
- Coagulation factors XI and XII
- High molecular weight kininogen
- TSP-1, integrin Mac-1, and P-selectin
The extracellular domain of CD42b also contributes to metastasis.
CD42b antigen is expressed on platelets and megakaryocytes in bone marrow.
Several polymorphisms and mutations in CD42b are linked to Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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