Thermo Fisher Scientific CD42b Monoclonal Antibody (AK2), PE

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• FITC
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD42b (GPIb alpha), a 135–145 kDa membrane glycoprotein expressed on platelets and megakaryocytes.
CD42b and CD42c (GPIb beta) form a disulfide-linked heterodimer (CD42b/c; 160 kDa), which associates noncovalently with CD42a and CD42d.

Target Information

CD42b is a platelet activation marker involved in coagulation as an aggregating factor.
It interacts with extracellular matrix and adhesion molecules, and its expression is regulated by VEGF and PDGF.
CD42b, together with GPIb beta, GPIX, and GPV, forms the GPIb-IX-V receptor complex, critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.

CD42b binds to:

• von Willebrand factor (VWF)
• Thrombin
• Coagulation factors XI and XII
• High molecular weight kininogen
• TSP-1, integrin Mac-1, and P-selectin

The extracellular domain of CD42b also contributes to metastasis.
CD42b antigen is expressed on platelets and megakaryocytes in bone marrow.
Several polymorphisms and mutations in CD42b are linked to Bernard-Soulier syndrome and platelet-type von Willebrand disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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