Thermo Fisher Scientific PD L1 (CD274) Monoclonal Antibody (OTI7D4)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. It binds specifically to the programmed death receptor 1 (PD-1), which negatively regulates T-cell receptor (TCR) signaling. PD-L1 interaction with PD-1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be upregulated upon IFN-gamma stimulation, suggesting its critical role in tumor immune evasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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