Thermo Fisher Scientific PEN2 Recombinant Rabbit Monoclonal Antibody (ARC1779)
PEN2 단백질을 인식하는 재조합 토끼 단클론 항체로 Western blot, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, HEK293 세포에서 발현된 IgG 형식입니다. 고순도 친화 크로마토그래피 정제 및 안정한 글리세롤 보존 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:400 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1779 |
| Immunogen | Recombinant fusion protein containing amino acids 1–101 of human PEN2/PSENEN (NP_758844.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898094 |
Product Specific Information
- Positive Samples: 293T, A-549, SH-SY5Y, Mouse kidney, Rat lung
- Immunogen sequence:
MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLVPAYTEQ SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT P
Target Information
Presenilins, components of the gamma-secretase complex, are essential for intramembranous processing of type I transmembrane proteins such as Notch and beta-amyloid precursor protein. Notch receptor signaling regulates diverse developmental cell fates. Processing of beta-amyloid precursor protein produces amyloid beta peptides, a major component of senile plaques linked to Alzheimer’s disease. This gene encodes a protein required for Notch pathway signaling and gamma-secretase activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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