Thermo Fisher Scientific ST2 Polyclonal Antibody
ST2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Flow Cytometry에 적합하며 KLH 결합 합성 펩타이드로부터 유래했습니다. Protein A로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications
- Flow Cytometry (Flow): 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Interleukin 1 receptor like 1, amino acids 11–110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family. Its extracellular domain has three Ig-like domains that interact with its co-receptor IL-1RAcP and the ligand IL-33. Upon IL-33 binding, the IL-33R complex associates with adaptor proteins MyD88, IRAK1, IRAK4, and TRAF6, activating NF-κB and MAPK pathways. This leads to the release of cytokines such as IL-5, IL-6, IL-8, and IL-13. Two main isoforms exist: ST2L (membrane-bound) and ST2S (soluble). The soluble form acts as a decoy to dampen IL-33 signaling. IL-33R is expressed mainly by mast cells, basophils, and eosinophils, and in mice, on ILC2 and Th2 cells. IL-33R signaling is implicated in immune conditions such as allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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