Thermo Fisher Scientific Fra1 Polyclonal Antibody

Thermo Fisher Scientific Fra1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Species Reactivity

• Mouse
• Rat

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus.
Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes.
In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family.
Selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun, exhibiting differential specificity and affinity for AP-1 and CRE sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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