Thermo Fisher Scientific Phospho-PDPK1 (Ser410) Polyclonal Antibody
Phospho-PDPK1 (Ser410) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 고품질 항체입니다. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human PDPK1 around the phosphorylation site of Ser410 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of key threonine residues in the activation loop.
It also phosphorylates Protein Kinase B (PKB/Akt) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Activated Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to glycogen synthase activation and glycogen synthesis stimulation.
Because PDPK1 plays a crucial role in insulin-induced glycogen synthesis and PKC activation, it is considered an important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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