Thermo Fisher Scientific APIP Polyclonal Antibody
Thermo Fisher Scientific의 APIP 폴리클로날 항체는 인간 APIP 단백질을 표적으로 하며 WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human APIP. Recombinant protein control fragment (Product #RP-92054) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790024 |
Product Specific Information
Immunogen sequence:
NTPEEKDLKD RMAHAMNEYP DSCAVLVRRH GVYVWGETWE KAKTMCECYD YLFDIAVSMK KVGLDPSQLP VGENGIV
Target Information
The mammalian homologues of the key cell death gene CED-4 in C. elegans have been identified from human and mouse and designated Apaf 1 (apoptosis protease-activating factor 1).
Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), leading to Caspase-9 activation. Activated Caspase-9 cleaves and activates Caspase-3, a key protease responsible for the proteolytic cleavage of many proteins in apoptosis.
Cho et al. identified a new Apaf 1 Interacting Protein (APIP, also known as CG129 and MMRP19), which acts as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1.
APIP is predicted to code for a 204 amino acid protein. An isoform, APIP2, encodes a 242 amino acid protein differing in its N-terminus.
APIP transcript is ubiquitously expressed in most adult tissues, with high expression in skeletal muscle, heart, and kidney.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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