Thermo Fisher Scientific AF1Q Monoclonal Antibody (2A9-1B7)
AF1Q 단백질을 인식하는 Thermo Fisher Scientific의 Mouse IgG2a 단클론 항체. Western blot 및 ELISA 검증 완료. 인간 시료 반응성, 보존제 무첨가 PBS 용액 형태. Leukemia 관련 MLLT11 연구에 적합.
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Applications
- Western Blot (WB): 1–5 µg/mL
- ELISA: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A9-1B7 |
| Immunogen | AF1Q (AAH09624, 1–90 a.a) full-length recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL
Target Information
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia.
t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated.
The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
This gene encodes 90 amino acids and is highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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