Thermo Fisher Scientific Adiponectin Receptor 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 5–10 µg/mL

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is colon, hippocampus, or trachea lysate.

Target Information

Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes.

This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors contain seven transmembrane domains and are distinct from G-protein-coupled receptors. Expression or suppression of AdipoR1/R2 confirms their role as receptors mediating adiponectin-induced AMP kinase and PPAR activation, fatty-acid oxidation, and glucose uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.