Thermo Fisher Scientific HOP Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HOP (AAH14225, 1 a.a. approximately 73 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HOPX,uniProtId:Q9BPY8-1,ncbiNodeId:9606,antigenRange:1-73,antigenLength:73,antigenImageFileName:H00084525-B01P_HOPX_Q9BPY8-1_House_mouse.svg,antigenImageFileNamePDP:H00084525-B01P_HOPX_Q9BPY8-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VID

Target Information

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.