Thermo Fisher Scientific BTBD12 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BTBD12 (AAH36335.1, 1 a.a. approximately 1151 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BTBD12,uniProtId:Q8IY92-1,ncbiNodeId:9606,antigenRange:1-1834,antigenLength:1834,antigenImageFileName:H00084464-B01P_BTBD12_Q8IY92-1_House_mouse.svg,antigenImageFileNamePDP:H00084464-B01P_BTBD12_Q8IY92-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MVNNPHLSDV QFQTDSGEVL YAHKFVLYAR CPLLIQYVNN EGFSAVEDGV LTQRVLLGDV STEAARTFLH YLYTADTGLP PGLSSELSSL AHRFGVSELV HLCEQVPIAT DSEGKPWEEK EAENCESRAE NFQELLRSMW ADEEEEAETL LKSKDHEEDQ ENVNEAEMEE IYEFAATQRK LLQEERAAGA GEDADWLEGG SPVSGQLLAG VQVQKQWDKV EEMEPLEPGR DEAATTWEKM GQCALPPPQG QHSGARGAEA PEQEAPEEAL GHSSCSSPSR DCQAERKEGS LPHSDDAGDY EQLFSSTQGE ISEPSQITSE PEEQSGAVRE RGLEVSHRLA PWQASPPHPC RFLLGPPQGG SPRGSHHTSG SSLSTPRSRG GTSQVGSPTL LSPAVPSKQK RDRSILTLSK EPGHQKGKER RSVLECRNKG VLMFPEKSLS IDLTQSNPDH SSSRSQKSSS KLNEEDEVIL LLDSDEELEL EQTKMKSISS DPLEEKKALE ISPRSCELFS IIDVDADQEP SQSPPRSEAV LQQEDEGALP ENRGSLGRRG APWLFCDRES SPSEASTTDT SWLVPATPLA SRSRDCSSQT QISSLRSGLA VQAVTQHTPR ASVGNREGNE VAQKFSVIRP QTPPPQTPSS CLTPVSPGTS DGRRQGHRSP SRPHPGGHPH SSPLAPHPIS GDRAHFSRRF LKHSPPGPSF LNQTPAGEVV EVGDSDDEQE VASHQANRSP PLDSDPPIPI DDCCWHMEPL SPIPIDHWNL ERTGPLSTSS PSRRMNEAAD SRDCRSPGLL DTTPIRGSCT TQRKLQEKSS GAGSLGNSRP SFLNSALWDV WDGEEQRPPE TPPPAQMPSA GGAQKPEGLE TPKGANRKKN LPPKVPITPM PQYSIMETPV LKKELDRFGV RPLPKRQMVL KLKEIFQYTH QTLDSDSEDE SQSSQPLLQA PHCQTLASQT YKPSRAGVHA QQEATTGPGA HRPKGPAKTK GPRHQRKHHE SITPPSRSPT KEAPPGLNDD AQIPASQESV ATSVDGSDSS LSSQSSSSCE FGAAFESAGE EEGEGEVSAS QAAVQAADTD EALRCYIRSK PALYQKVLLY QPFELRELQA ELRQNGLRVS SRRLLDFLDT HCITFTTAAT RREKLQGRRR QPRGKKKVER N

Target Information

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.