Thermo Fisher Scientific PACS2 Polyclonal Antibody
PACS2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot, IHC, ELISA에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.02% sodium azide가 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| ELISA | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 17 amino acid peptide near the center of human PACS2 (amino acids 330–380) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718720 |
Target Information
PACS2 is a multifunctional sorting protein that controls endoplasmic reticulum (ER)–mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In response to apoptotic inducers, PACS2 translocates BID to mitochondria, initiating mitochondrial truncated BID formation, cytochrome c release, and caspase-3 activation, leading to cell death. PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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