Thermo Fisher Scientific COX2 Polyclonal Antibody
COX2 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 생쥐, 랫트 반응성. Western blot, IHC, ELISA 등 다양한 응용에 적합. 고순도 Affinity Chromatography 정제, 안정적 PBS/glycerol buffer 보존.
- 카탈로그번호
- PA588606
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific COX2 Polyclonal Antibody
Thermo Fisher Scientific COX2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 375–604 of COX2/PTGS2 (NP_000954.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805028 |
Product Specific Information
- Positive Samples: A-549, HeLa, Mouse spleen, Mouse lung, Rat lung, Rat kidney
- Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein
Immunogen Sequence:
PLLPDTFQIH DQKYNYQQFI YNNSILLEHG ITQFVESFTR QIAGRVAGGR NVPPAVQKVS QASIDQSRQM KYQSFNEYRK RFMLKPYESF EELTGEKEMS AELEALYGDI DAVELYPALL VEKPRPDAIF GETMVEVGAP FSLKGLMGNV ICSPAYWKPS TFGGEVGFQI INTASIQSLI CNNVKGCPFT SFSVPDPELI KTVTINASSS RSGLDDINPT VLLKERSTEL
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a key step in prostanoid synthesis and inflammatory prostaglandin production. The reaction proceeds via a cyclooxygenase (COX) activity forming PGG2, followed by a peroxidase activity reducing PGG2 to PGH2.
COX2 is constitutively expressed in certain tissues (endothelium, kidney, brain) and up-regulated under pathological conditions such as cancer and inflammation. Increased COX2 levels are linked to enhanced cell adhesion, resistance to apoptosis, and tumor angiogenesis.
COX2 is inhibited by calcitriol (active Vitamin D) and glucocorticoids can repress PTGS2 gene activity. NSAIDs such as aspirin target COX2 to reduce pain and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-88606_COX2_P35354-1_Rabbit.svg, PA5-88606_COX2_P35354-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.