Thermo Fisher Scientific FSTL1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, Jurkat
• Predicted reactivity: Mouse (94%), Rat (95%), Chicken (88%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Follistatin-like protein 1 (FSTL1) is a widely expressed extracellular glycoprotein belonging to the osteonectin (BM-40/SPARC) family, characterized by follistatin-like and extracellular calcium-binding domains. Initially identified as a TGF-beta-inducible protein in mouse osteoblasts, FSTL1 is involved in various cellular functions such as proliferation, differentiation, apoptosis, and migration.

It plays roles in embryonic development, inflammation, angiogenesis, tumorigenesis, and immune disease pathogenesis. FSTL1 expression can be upregulated by innate immune mediators like TLR4 agonists and IL-1β via NF-κB signaling, promoting pro-inflammatory cytokine secretion (TNF-α, IL-1β, IL-6, IL-8). While mesenchymal cells can produce FSTL1, hematopoietic cells typically do not, except under inflammatory conditions where macrophages and monocytes may uptake FSTL1 and induce caspase-1 activation.

Overexpression of FSTL1 is linked to rheumatoid arthritis (RA) and osteoarthritis (OA), whereas reduced serum levels are associated with ovarian and endometrial cancers, influencing cell proliferation and migration.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.