Thermo Fisher Scientific TNPO3 Recombinant Rabbit Monoclonal Antibody (ARC2310)
TNPO3 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA 등에 적합합니다. 인간, 마우스, 랫트 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2310 |
| Immunogen | Synthetic peptide corresponding to amino acids 824–923 of human Transportin 3 (TNPO3, Q9Y5L0) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.65 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897909 |
Product Specific Information
- Positive Samples: HeLa, RD, Jurkat, Mouse lung, Mouse testis, Mouse thymus, Rat testis
- Immunogen Sequence:
QVMNQLGQQL VSQLLHTCCF CLPPYTLPDV AEVLWEIMQV DRPTFCRWLE NSLKGLPKET TVGAVTVTHK QLTDFHKQVT SAEECKQVCW ALRDFTRLFR
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for essential splicing factors termed SR proteins. It binds directly to the arginine/serine (RS)-rich domains of these proteins, an interaction that occurs only when RS domains are phosphorylated. TNPO3 has been identified as an HIV dependency factor (HDF), where depletion inhibits HIV after reverse transcription but before integration, suggesting TNPO3 may serve as a potential drug target in HIV treatment. At least three isoforms of TNPO3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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