Thermo Fisher Scientific ATP Citrate Lyase Polyclonal Antibody
ATP Citrate Lyase 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등에 적합. 인간, 생쥐, 랫드 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 752–1101 of human ACLY (NP_0010872) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.82 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806026 |
Product Specific Information
Immunogen sequence:
FSSEVQFGHA GACANQASET AVAKNQALKE AGVFVPRSFD ELGEIIQSVY EDLVANGVIV PAQEVPPPTV PMDYSWAREL GLIRKPASFM TSICDERGQE LIYAGMPITE VFKEEMGIGG VLGLLWFQKR LPKYSCQFIE MCLMVTADHG PAVSGAHNTI ICARAGKDLV SSLTSGLLTI GDRFGGALDA AAKMFSKAFD SGIIPMEFVN KMKKEGKLIM GIGHRVKSIN NPDMRVQILK DYVRQHFPAT PLLDYALEVE KITTSKKPNL ILNVDGLIGV AFVDMLRNCG SFTREEADEY IDIGALNGIF VLGRSMGFIG HYLDQKRLKQ GLYRHPWDDI SYVLPEHMSM
Positive Samples: HepG2, HeLa, Raji, NIH/3T3, Mouse brain, Mouse heart, Mouse kidney, Rat brain
Cellular Location: Cytoplasm
Target Information
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate.
Acetyl-CoA serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate lyase may be involved in the biosynthesis of acetylcholine.
Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-90320_ATP_Citrate_Lyase_P53396-1_Rabbit.svg)
(이미지: PA5-90320_ATP_Citrate_Lyase_P53396-1_Rabbit_PDP.jpeg)
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