Thermo Fisher Scientific TEK Polyclonal Antibody
Rabbit polyclonal antibody against human TEK (TIE2) for endothelial cell research. Recombinant protein immunogen-based, unconjugated liquid form. Suitable for vascular biology studies. Store at 4°C short term or -20°C long term.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human TEK (TIE2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2857120 |
Product Specific Information
Immunogen sequence:
VISWTILDGY SISSITIRYK VQGKNEDQHV DVKIKNATIT QYQLKGLEPE TAYQVDIFAE NNIGSSNPAF SHELVTLPES QAPADL
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells.
TEK signaling is critical for endothelial cell–smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development.
Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP.
HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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