Thermo Fisher Scientific CD27 Monoclonal Antibody (CLB-27/1), FITC
인간 CD27을 인식하는 마우스 모노클로날 항체로 FITC 형광 표지됨. 세포 분석 및 유세포분석(Flow Cytometry)에 적합. 높은 형광 효율과 수용성, 안정적인 저장 조건 제공. CD27 관련 림프구 활성 및 질환 연구에 유용.
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Applications
- Flow Cytometry (Flow): Assay-dependent
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLB-27/1 |
| Immunogen | Human CD27 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10373684 |
Additional Formats
- APC-Alexa Fluor 750
- PE
- Qdot 605
- Qdot 655
- Request custom conjugation
Product Specific Information
FITC conjugates provide high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them suitable for flow cytometry and fluorescence-based assays.
Target Information
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily, including CD40 and CD30. It regulates cell proliferation and death, primarily expressed on lymphocytes.
CD27 forms disulfide-linked homodimers on mature thymocytes, peripheral blood T cells, and certain B cell subsets. Activation via TCR-CD3 upregulates CD27 and releases soluble CD27 (sCD27), found in plasma, urine, or spinal fluid.
Soluble CD27 serves as a prognostic marker in B cell malignancies. CD27-binding protein (SIVA) is a proapoptotic factor associated with CD27-mediated apoptosis.
Diseases linked to CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
Classification
Analyte Specific Reagent
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배송/결제/교환/반품 안내
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