Thermo Fisher Scientific Phospho-FOXO1 (Ser249) Polyclonal Antibody
FOXO1 단백질의 Ser249 인산화 상태를 특이적으로 인식하는 polyclonal antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 사람, 생쥐, 랫드 반응성. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FOXO1 (Accession Q12778), corresponding to amino acid residues around phosphorylated Ser249. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817395 |
Product Specific Information
This antibody detects endogenous levels of FOXO1A only when phosphorylated at Ser249.
Target Information
FOXO1 (FKHR, Forkhead Box O1) belongs to the forkhead homeotic gene family of transcription factors. It can function as both a coactivator and corepressor of nuclear receptor activity via the LXXLL motif in its C-terminal region. Association with PAX3 is linked to alveolar rhabdomyosarcoma. FOXO1 is involved in autophagy, myogenic differentiation, and acts as a key regulator of insulin signaling, oxidative stress response, and metabolic homeostasis. It binds to insulin response elements (IRE) and Daf-16 family binding elements (DBE) to regulate gene transcription. FOXO1 also influences bone mass, glucose metabolism, and hepatocyte gluconeogenesis by activating genes such as IGFBP1, G6PC, and PCK1. It functions downstream of CDK1, PKB/AKT1, and MST1 to regulate cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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