Thermo Fisher Scientific PGRMC2 Polyclonal Antibody
PGRMC2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 인간 시료에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | – |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | – |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PGRMC2. Recombinant protein control fragment (Product #RP-95669). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645460 |
Product Specific Information
Immunogen sequence:
RWRAVMAAGD GDVKLGTLGS GSESSNDGGS ESPCDA
Antigen sequence identity:
- Mouse: 53%
- Rat: 50%
Target Information
PGRMC2 (Progesterone Receptor Membrane Component 2)
Also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), PGRMC2 is a single-pass membrane protein belonging to the cytochrome b5 family (MAPR subfamily). It is expressed in sperm and is believed to function as a steroid receptor, potentially participating in the progesterone-dependent sperm acrosome reaction.
PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, suggesting a potential role in metastasis suppression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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