Thermo Fisher Scientific RPA4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total RPA30.

Target Information

The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, mitochondria, phages, and viruses. Replication protein A (RPA), a highly conserved eukaryotic protein, is a heterotrimeric SSB consisting of three subunits that play an important role in DNA replication, recombination, and repair. RPA is one of the major damage-recognition structures involved in the early stage of nucleotide excision repair and may function in telomere maintenance. The binding of human RPA (hRPA) to DNA involves molecular polarity, in which initial hRPA binding occurs on the 5′ side of a ssDNA substrate and then extends in the 3′ direction to create a stably bound hRPA. Widely expressed at low to intermediate levels, RPA 34 kDa subunit, also known as RPA4 (replication factor A protein 4), contains 261 amino acids, localizes to the nucleus, and is preferentially expressed in mucosa of colon and placenta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.