Thermo Fisher Scientific SIRT1 Recombinant Rabbit Monoclonal Antibody (4H9L12)

Applications

Western Blot (WB)

• Tested Dilution: 1:250

ChIP assay (ChIP)

• Tested Dilution: 2 µg/million cells

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, and Cat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and coordinates several cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis, and autophagy.

SIRT1 modulates chromatin function through histone deacetylation and promotes changes in histone and DNA methylation, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and mediates inhibitory effects on skeletal myoblast differentiation under low nutrient conditions, involving AMPK and NAMPT pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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