Thermo Fisher Scientific 4-1BB Monoclonal Antibody (8C10)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1- 5 µg/mL

-

ELISA (ELISA)

0.01-0.05 µg/mL

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

8C10

Immunogen

Recombinant 4-1BB protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

4-1BB, also known as CD137, is a type I membrane glycoprotein, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells. 4-1BB is involved in the activation and survival of CD4+ or CD8+ T cells, and NK cells. It can induce monocyte activation through its interaction with 4-1BB ligand.
Human 4-1BB Antibody (8C10), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with 4-1BB.

Target Information

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.