Thermo Fisher Scientific Phospho-DNA-PK (Thr2609) Polyclonal Antibody
DNA-PK의 Thr2609 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot과 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트 시료 반응. 1 mg/mL 농도의 액상 형태로 제공되며 -20°C에서 보관.
- 카탈로그번호
- PA5105749
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKDC (Accession P78527), corresponding to amino acid residues around phosphorylated Thr2609 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817148 |
Product Specific Information
Antibody detects endogenous levels of DNA-PK only when phosphorylated at Thr2609.
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase, closely related to the PI3 kinases, and is often inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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