Thermo Fisher Scientific MCU Polyclonal Antibody
Rabbit polyclonal antibody targeting human MCU protein. Validated for Western blot and immunoprecipitation. Suitable for studying mitochondrial calcium uptake and regulation. Supplied in liquid form, purified by antigen affinity chromatography. For res...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–5 µL/mg of lysate |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human MCU fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902658 |
Target Information
Mitochondrial inner membrane calcium uniporter (MCU) mediates calcium uptake into mitochondria and forms the pore-forming subunit of the uniporter complex. Its activity is regulated by MICU1 and MICU2: inhibited at low Ca²⁺ levels and activated at higher levels. MCU plays a central role in mitochondrial calcium homeostasis, influencing cellular physiology, energy metabolism, and apoptosis regulation.
It contributes to buffering systolic calcium levels in cardiomyocytes and supports the “fight-or-flight” response by enabling rapid mitochondrial calcium uptake in pacemaker cells. MCU is also implicated in mitochondrial permeability transition during ischemia-reperfusion injury, glucose-dependent insulin secretion in pancreatic β-cells, muscle size regulation in skeletal muscle, and synaptic vesicle endocytosis in the nervous system. Additionally, it participates in antigen processing and presentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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