Thermo Fisher Scientific OVCA2 Polyclonal Antibody
Human OVCA2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 고순도 항원 친화 크로마토그래피로 정제. PBS/glycerol buffer에 보존되어 장기 안정성 우수. 연구용으로 암 관련 유전자 OVCA2 분석에 적합.
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Thermo Fisher Scientific OVCA2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human OVCA2. Recombinant protein control fragment (Product #RP-105120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664253 |
Product Specific Information
- Immunogen sequence:
PLPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE - Antigen sequence identity:
Mouse 85%, Rat 31%
Target Information
Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu, and others.
OVCA1 and OVCA2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers.
OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast, and other tumor types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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