Thermo Fisher Scientific CHST1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 mediates the sulfation of keratan in the cornea, which is important for maintaining corneal transparency. Specifically, CHST1 catalyzes the transfer of sulfate groups from 3′-phosphoadenosine 5′-phosphosulfate to position six of internal or terminal galactose residues (preferentially adjacent to sulfated GlcNAc) on growing keratan sulfate chains. CHST1 also contributes to the generation of L-selectin ligands. Mutations in the CHST1 gene may play a role in macular corneal dystrophy (MCD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.