Thermo Fisher Scientific NF2 Polyclonal Antibody
NF2 단백질(Merlin)을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | – |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NF2. Recombinant protein control fragment (Product #RP-91529) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789221 |
Product Specific Information
Immunogen sequence:
ERRA KQKLLE IATKPTYPPM NPIPAPLPPD IPSFNLIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT EIEALKLKER ETALDILHNE NSDRGGSSKH NTIKKLTLQS AKSRVA
Target Information
NF2 encodes a protein, Merlin, that is similar to members of the ERM family, which link cytoskeletal components with membrane proteins. Merlin interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics, and ion transport regulation.
This gene is highly expressed during embryonic development and in adults is found in Schwann cells, meningeal cells, lens, and nerve.
Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors and ocular abnormalities.
Two predominant and several minor isoforms are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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