Thermo Fisher Scientific ELOVL6 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

• Immunogen sequence: VLTLQEYEFE KQFNENEAIQ WMQENWKKS
• Highest antigen sequence identity: Mouse - 100%, Rat - 100%

Target Information

Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1.
Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of the fatty acyl-CoA elongase gene family that converts palmitic to stearic acid.
It is a known target of SREBP-1 and plays an important role in de novo synthesis of long-chain saturated and monounsaturated fatty acids, in conjunction with fatty acid synthase and stearoyl-CoA desaturase.
ELOVL6 is predicted to be important for tissue fatty acid composition.
Recent studies suggest that inhibition of this elongase could be a potential therapeutic approach for ameliorating insulin resistance, diabetes, and cardiovascular risks, even in obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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