Thermo Fisher Scientific MIA Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

• Immunogen sequence:
  PKLADRKLCA DQECSHPISM AVALQDYMAP DCRFLTIHRG QVVYVFSKLK GRGRLFWGGS VQGDYYGDLA ARLGYFPSSI VREDQTLKPG KVDVKTDKWD FYC
• Highest antigen sequence identity to the following orthologs:
  Mouse - 91%, Rat - 93%.

Target Information

Tumorigenesis is mediated by a network of membrane, cytosolic, and nuclear-associated factors regulating proliferation and cell-matrix interactions through signaling cascades.
Melanoma inhibitory activity (MIA, cartilage-derived retinoic acid-sensitive protein, CD-RAP) is a SH3-like domain-containing protein secreted from chondrocytes and malignant melanoma cells.
MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal.
It is expressed during chondrogenesis and in mature chondrocytes, suggesting its role in maintaining normal cartilage cell phenotype.
MIA mRNA is also found in carcinomas of the colon, ovary, kidney, and head/neck, and may serve as a marker for monitoring melanomic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.