Thermo Fisher Scientific MIA Polyclonal Antibody
Thermo Fisher Scientific의 MIA Polyclonal Antibody는 인간 MIA 단백질을 인식하는 토끼 유래 IgG 항체입니다. IHC(P)에서 1:200~1:500 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기, -20°C 장기 보관이 권장됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MIA. Recombinant protein control fragment (Product #RP-90572). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643945 |
Product Specific Information
- Immunogen sequence:
PKLADRKLCA DQECSHPISM AVALQDYMAP DCRFLTIHRG QVVYVFSKLK GRGRLFWGGS VQGDYYGDLA ARLGYFPSSI VREDQTLKPG KVDVKTDKWD FYC - Highest antigen sequence identity to the following orthologs:
Mouse - 91%, Rat - 93%.
Target Information
Tumorigenesis is mediated by a network of membrane, cytosolic, and nuclear-associated factors regulating proliferation and cell-matrix interactions through signaling cascades.
Melanoma inhibitory activity (MIA, cartilage-derived retinoic acid-sensitive protein, CD-RAP) is a SH3-like domain-containing protein secreted from chondrocytes and malignant melanoma cells.
MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal.
It is expressed during chondrogenesis and in mature chondrocytes, suggesting its role in maintaining normal cartilage cell phenotype.
MIA mRNA is also found in carcinomas of the colon, ovary, kidney, and head/neck, and may serve as a marker for monitoring melanomic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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