Thermo Fisher Scientific CEACAM1 (CEA Cell Adhesion Molecule 1) Monoclonal Antibody (CEACAM1/4837)
Human CEACAM1 단백질을 인식하는 Mouse 단일클론 항체로, IHC(P)에서 1–2 µg/mL로 사용 가능. 단백질 A/G로 정제된 액상형 항체이며, PBS + 0.05% BSA 버퍼에 보관. 세포막 및 세포 간 접촉 부위에 위치하는 CEACAM1 검출에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CEACAM1/4837 |
| Immunogen | Recombinant fragment (around aa 50–250) of human CEACAM1 protein (CD66a, UniProt ID: P13688-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Endometrium; Human colon, liver, or hepatic carcinoma tissues
- Cellular Location: Secreted; Cell membrane; Localizes to sites of cell–cell contact
Target Information
CEACAM1 (CEA Cell Adhesion Molecule 1) is a member of the carcinoembryonic antigen (CEA) gene family within the immunoglobulin superfamily.
It is located on chromosome 19 within a 1.2 Mb cluster containing CEA cell adhesion molecules and pregnancy-specific glycoproteins.
Originally identified as biliary glycoprotein in liver bile ducts, CEACAM1 functions as a cell–cell adhesion molecule found on leukocytes, epithelial, and endothelial cells.
It mediates homophilic and heterophilic interactions and plays roles in:
- Tissue differentiation and structural organization
- Angiogenesis and apoptosis
- Tumor suppression and metastasis
- Modulation of innate and adaptive immune responses
Multiple transcript variants exist, with two full-length isoforms characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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