Thermo Fisher Scientific TPA Polyclonal Antibody
TPA 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A로 정제된 고순도 항체로 -20°C에서 안정적 보관 가능.
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Thermo Fisher Scientific TPA Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Tissue-type plasminogen activator chain B, amino acids 401–500 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TPA converts the abundant but inactive zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling, degradation, cell migration, and various physiological and pathological events.
It specifically cleaves the Arg-Val bond in plasminogen to form plasmin and is composed of a heterodimer of chain A and chain B connected by a disulfide bond.
TPA binds to fibrin with high affinity, which increases the catalytic efficiency between 100–1000-fold by enhancing affinity for plasminogen. Binding to heparin also increases plasminogen activation.
Additionally, TPA binds to laminin, fibronectin, mannose receptor, and LRP1, which are involved in TPA clearance. It also interacts with annexin II and cytokeratin 8.
Unidentified interactions on endothelial and vascular smooth muscle cells lead to a 100-fold stimulation of plasminogen activation, while binding to VSMC reduces TPA inhibition by PAI-1 approximately 30-fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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