Thermo Fisher Scientific Phospho-C-Myc (Thr58) Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal 항체로 c-Myc Thr58 인산화 부위를 인식. Western blot, IHC, ELISA에 적합하며 Protein A 정제 및 고농도(1 mg/mL) 액상 형태. 암세포 내 c-Myc 관련 신호전달 및 세포주기 연구용으로 최적화.
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Thermo Fisher Scientific Phospho-C-Myc (Thr58) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthesized phosphopeptide derived from human C-Myc around the phosphorylation site of Thr58 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with cell cycle regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins with Myc epitope tags fused to either amino- or carboxy-termini of target proteins.
Amplification of the c-Myc gene is observed in various human tumors including lung, breast, and colon carcinomas. Translocation of the c-Myc locus to immunoglobulin loci is described in Burkitt’s lymphoma and other B-cell lymphoproliferative diseases. Aberrant expression occurs in tumors of colorectal, gastric, hepatic, mammary, ovarian, pulmonary, thyroidal, and hematopoietic origins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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