Thermo Fisher Scientific Nectin-1/PVRL1 (extracellular) Polyclonal Antibody, FITC

Applications

• Flow Cytometry (Flow): Tested dilution 5 µg

Product Specifications

Product Specific Information

• Reconstitution: Add 15 µL or 50 µL double distilled water (DDW) depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Target Information

Nectin-1 (PVRL1) encodes an adhesion protein involved in the organization of adherens and tight junctions in epithelial and endothelial cells. It is a calcium-independent cell-cell adhesion molecule belonging to the immunoglobulin superfamily, containing three extracellular Ig-like loops, a single transmembrane domain, and a cytoplasmic region.
This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus, mediating viral entry into epithelial and neuronal cells.
Mutations in this gene are associated with cleft lip and palate/ectodermal dysplasia 1 syndrome and non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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