Thermo Fisher Scientific TMEM2 Polyclonal Antibody
TMEM2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 시료에 반응하며 ICC/IF에 적합. 재조합 단백질 항원을 면역원으로 사용. 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 1226–1364). Recombinant protein control fragment (Product #RP-109718). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092034 |
Product Specific Information
Immunogen sequence:
GDPSVISVNG TDFTFRSAGV LLLVVDPCSV PFRLTEKTVF PLADVSRIEE YLKTGIPPRS IVLLSTRGEI KQLNISHLLV PLGLAKPAHL YDKGSTIFLG FSGNFKPSWT KLFTSPAGQG LGVLEQFIPL QLDEYGCPR
Antigen sequence identity:
- Mouse: 79%
- Rat: 78%
Target Information
This gene encodes a type II transmembrane protein belonging to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also exhibits interferon-mediated antiviral activity through activation of the JAK-STAT signaling pathway. Activation by transcription factor SOX4 in breast cancer cells mediates the pathological effects of SOX4 on cancer progression. Mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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