Thermo Fisher Scientific TMEM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 1226-1364. Recombinant protein control fragment (Product #RP-109718). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM2,uniProtId:Q9UHN6-1,ncbiNodeId:9606,antigenRange:1226-1364,antigenLength:1383,antigenImageFileName:PA5-144720_TMEM2_Q9UHN6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144720_TMEM2_Q9UHN6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092034

Product Specific Information

Immunogen sequence: GDPSVISVNG TDFTFRSAGV LLLVVDPCSV PFRLTEKTVF PLADVSRIEE YLKTGIPPRS IVLLSTRGEI KQLNISHLLV PLGLAKPAHL YDKGSTIFLG FSGNFKPSWT KLFTSPAGQG LGVLEQFIPL QLDEYGCPR

Antigen sequence identity: Mouse 79%; Rat 78%

Target Information

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.