Thermo Fisher Scientific IL-22 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I and II interferons.
It is primarily produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10. IL-22 acts through a heterodimeric receptor complex composed of IL-22R1 and IL-10R2. IL-22R1 also binds IL-20 and IL-24, while IL-10R2 binds IL-10, IL-27, IL-28, and IL-29.

Binding of IL-22 to its receptor complex triggers signal transduction via the JAK-STAT pathway. A soluble IL-22 receptor (IL-22BP) can antagonize IL-22 binding and signaling. IL-22 primarily targets non-immune cells such as those in the skin, digestive tract, respiratory system, liver, and keratinocytes.

It is an effector cytokine of the Th17 lineage, co-expressed with IL-17A and IL-17F, and regulates genes associated with innate immunity of the skin. IL-22 induces acute phase reactants and antimicrobial proteins, enhances keratinocyte mobility, and plays a role in host defense, chronic inflammation, and wound healing.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.