Thermo Fisher Scientific IL-22 Polyclonal Antibody
다양한 응용 분야(WB, IHC, ICC, Flow, ELISA)에 사용 가능한 IL-22 폴리클로날 항체. Rabbit IgG로 제작되었으며 Human, Mouse, Rat 반응성. Protein A로 정제된 액상 형태로, 안정적인 보관(-20°C) 가능. 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-22, amino acids 35–179 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I and II interferons.
It is primarily produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10. IL-22 acts through a heterodimeric receptor complex composed of IL-22R1 and IL-10R2. IL-22R1 also binds IL-20 and IL-24, while IL-10R2 binds IL-10, IL-27, IL-28, and IL-29.
Binding of IL-22 to its receptor complex triggers signal transduction via the JAK-STAT pathway. A soluble IL-22 receptor (IL-22BP) can antagonize IL-22 binding and signaling. IL-22 primarily targets non-immune cells such as those in the skin, digestive tract, respiratory system, liver, and keratinocytes.
It is an effector cytokine of the Th17 lineage, co-expressed with IL-17A and IL-17F, and regulates genes associated with innate immunity of the skin. IL-22 induces acute phase reactants and antimicrobial proteins, enhances keratinocyte mobility, and plays a role in host defense, chronic inflammation, and wound healing.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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