Thermo Fisher Scientific Phospho-ATF2 (Ser480) Polyclonal Antibody
Phospho-ATF2 (Ser480) 폴리클로날 항체로, Western blot 및 IHC(P) 분석에 적합합니다. Rabbit IgG 유래 비결합형 항체이며, 액상 형태로 제공됩니다. ATF2 단백질의 Ser480 인산화 부위를 인식합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Ser480 (P-S-SP-Q-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555027 |
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress, such as genotoxic agents, inflammatory cytokines, and UV irradiation, stimulates the transcriptional activity of ATF-2.
Activation occurs through phosphorylation of Thr69 and Thr71 by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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