Thermo Fisher Scientific GluR6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GRIK2.

Target Information

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes.
The kainate family of glutamate receptors, composed of four subunits functioning as ligand-activated ion channels, includes this gene product.
The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, altering receptor structure and function.
Different isoforms have been described due to alternatively spliced transcript variants.
Mutations in this gene have been linked to autosomal recessive cognitive disability.
GRIK2-associated diseases include:

• Neurodevelopmental Disorder with Impaired Language and Ataxia (with or without Seizures)
• Intellectual Developmental Disorder, Autosomal Recessive 6

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.