Thermo Fisher Scientific 5HT2C R Polyclonal Antibody
5HT2C 수용체를 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. Mouse와 Rat 시료에 반응하며, 합성 펩타이드(aa 420-460)를 면역원으로 사용. 동결건조 형태로 제공되며, 4°C 단기 또는 -20°C 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 420–460 of mouse 5HT2C receptor conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and shares 95% identity with human sequence.
- Specificity: 5HT2C receptor.
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates various physiological effects through several receptor subtypes, including the 5-HT2 family of G-protein-coupled receptors.
The 5-HT2C receptor activates phospholipase C and D signaling pathways. Its mRNA undergoes multiple RNA editing events, converting adenosine to inosine, altering amino acids within the second intracellular loop.
These modifications produce receptor isoforms with differing G protein interactions and signaling capabilities, modulating serotonergic neurotransmission in the CNS.
Abnormal 5-HT2C RNA editing patterns have been reported in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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