Thermo Fisher Scientific PLCE1 Polyclonal Antibody
Human PLCE1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.4 mg/mL 농도의 액상 형태로 제공. 세포 성장 및 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PLCE1. Recombinant protein control fragment (Product # RP-90791) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645632 |
Product Specific Information
Immunogen sequence:
MGISPLGNQS VIIETGRAHP DSRRAVFHFH YEVDRRMSDT FCTLSENLIL DDCGNCVPLP GGEEKQKKNY VAYTCKLMEL AKNCDNKNEQ LQCDHCDTLN DKYFCFEGSC EKVDMVYSGD SFCRKDFTDS QAAKT
Antigen sequence identity:
- Mouse: 59%
- Rat: 57%
Target Information
The PLCE1 gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
These messengers regulate various cellular processes including growth, differentiation, and gene expression.
This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins.
In addition to its phospholipase C catalytic activity, it possesses an N-terminal domain with guanine nucleotide exchange (GEF) activity.
Mutations in this gene are associated with early-onset nephrotic syndrome, characterized by proteinuria, edema, and mesangial sclerosis or focal and segmental glomerulosclerosis.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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