Thermo Fisher Scientific uPAR Polyclonal Antibody
uPAR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. Human 시료에 반응하며, 액상 형태로 제공. PBS와 sucrose buffer에 보관되며 -20°C에서 보관 권장. 세포 표면 uPAR 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of uPAR (target family: uPAR (CD87), UniProt ID: Q03405-1, antigen range: 1–335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2690873 |
Product Specific Information
This target displays homology in the following species:
- Human: 100%
- Mouse: 82%
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
The human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide (22 residues) and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) in monocytes, anchored to the plasma membrane by a glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) associates with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. UPAR protein expression is positively correlated with recurrence rate and mortality in endometrial cancer patients, making UPAR a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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