Thermo Fisher Scientific uPAR Polyclonal Antibody
uPAR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 사용 가능. Human 시료에 반응하며, 액상 형태로 제공. PBS와 sucrose buffer에 보관되며 -20°C에서 보관 권장. 세포 표면 uPAR 연구에 적합.
- 카탈로그번호
- PA570606
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific uPAR Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of uPAR (target family: uPAR (CD87), UniProt ID: Q03405-1, antigen range: 1–335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2690873 |
Product Specific Information
This target displays homology in the following species:
- Human: 100%
- Mouse: 82%
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
The human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide (22 residues) and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) in monocytes, anchored to the plasma membrane by a glycosyl-phosphatidylinositol linkage.
PLAUR (UPAR) associates with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. UPAR protein expression is positively correlated with recurrence rate and mortality in endometrial cancer patients, making UPAR a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.