Thermo Fisher Scientific VEGFB Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 VEGFB Polyclonal Antibody는 인간 VEGFB 단백질을 인식하는 Mouse IgG 폴리클론 항체입니다. Western blot에 적합하며, 액상 형태로 제공됩니다. PBS 버퍼에 보관하며 -20°C에서 안정적입니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | VEGFB (NP_003368, 1–207 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MSPLLRRLLL AALLQLAPAQ APVSQPDAPG HQRKVVSWID VYTRATCQPR EVVVPLTVEL MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIRYPSSQ LGEMSLEEHS QCECRPKKKD SAVKPDRAAT PHHRPQPRSV PGWDSAPGAP SPADITHPTP APGPSAHAAP STTSALTPGP AAAAADAAAS SVAKGGA
Target Information
Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors characterized by a conserved pattern of eight cysteine residues and common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis.
VEGFB shares structural similarities with VEGF and PIGF and is often co-expressed with VEGF. Two alternatively spliced isoforms exist: VEGFB167 and VEGFB186. VEGFB167 is a heparin-binding protein associated with cells or extracellular matrix, while VEGFB186 is secreted.
VEGFB binds to VEGFR1 (flt1) but not VEGFR2, and is highly expressed in heart, skeletal muscle, and pancreas. Expression of VEGFB in human breast cancers has been linked to lymph node metastasis. The VEGFB gene is mapped to chromosome 11q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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