Thermo Fisher Scientific DTL Polyclonal Antibody
Thermo Fisher Scientific의 DTL Polyclonal Antibody는 인간 DTL 단백질의 N-말단 펩타이드(aa 182-231)에 특이적으로 반응하는 토끼 유래 IgG 항체입니다. Western blot에 적합하며, 세포 주기 조절 및 DNA 손상 반응 연구에 활용됩니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human DTL (aa 182–231) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576882 |
Product Specific Information
- Peptide sequence:
VNQISGAHNT SDKQTPSKPK KKQNSKGLAP SVDFQQSVTV VLFQDENTLV - Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 86%
Rat: 100%
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response, and translesion DNA synthesis.
The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage ensures proper cell cycle regulation of DNA replication.
CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require interaction with PCNA via their PIP-box, recruiting the DCX(DTL) complex for degradation.
In undamaged proliferating cells, the DCX(DTL) complex promotes Lys-164 monoubiquitination of PCNA, contributing to PCNA-dependent translesion DNA synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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